prikaz prve stranice dokumenta β Cells Operate Collectively to Help Maintain Glucose Homeostasis
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Scientific paper - Original scientific paper
β Cells Operate Collectively to Help Maintain Glucose Homeostasis
Biophysical Journal, 118 (2020), 10; 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005
Podobnik, Boris; Korošak, Dean; Skelin Klemen, Maša; Stožer, Andraž; Dolenšek, Jurij; Slak Rupnik, Marjan; Ivanov, Plamen Ch.; Holme, Petter; Jusup, Marko

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Podobnik, B., Korošak, D., Skelin Klemen, M., Stožer, A., Dolenšek, J., Slak Rupnik, M. ... Jusup, M. (2020). β Cells Operate Collectively to Help Maintain Glucose Homeostasis. Biophysical Journal, 118. (10), 2588-2595. doi: 10.1016/j.bpj.2020.04.005

Podobnik, Boris, et al. "β Cells Operate Collectively to Help Maintain Glucose Homeostasis." Biophysical Journal, vol. 118, no. 10, 2020, pp. 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005

Podobnik, Boris, Dean Korošak, Maša Skelin Klemen, Andraž Stožer, Jurij Dolenšek, Marjan Slak Rupnik, Plamen Ch. Ivanov, Petter Holme and Marko Jusup. "β Cells Operate Collectively to Help Maintain Glucose Homeostasis." Biophysical Journal 118, no. 10 (2020): 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005

Podobnik, B., et al. (2020) 'β Cells Operate Collectively to Help Maintain Glucose Homeostasis', Biophysical Journal, 118(10), pp. 2588-2595. doi: 10.1016/j.bpj.2020.04.005

Podobnik B, Korošak D, Skelin Klemen M, Stožer A, Dolenšek J, Slak Rupnik M, and sur.. β Cells Operate Collectively to Help Maintain Glucose Homeostasis. Biophysical Journal [Internet]. 2020 May [cited 2025 April 06];118(10):2588-2595. doi: 10.1016/j.bpj.2020.04.005

B. Podobnik, et al., "β Cells Operate Collectively to Help Maintain Glucose Homeostasis", Biophysical Journal, vol. 118, no. 10, pp. 2588-2595, May 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:157:390293. [Accessed: 06 April 2025]

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Metadata
Title (english)β Cells Operate Collectively to Help Maintain Glucose Homeostasis
AuthorBoris Podobnik
AuthorDean Korošak
AuthorMaša Skelin Klemen
AuthorAndraž Stožer
AuthorJurij Dolenšek
AuthorMarjan Slak Rupnik
AuthorPlamen Ch. Ivanov
AuthorPetter Holme
AuthorMarko Jusup
Author's institutionZagreb School of Economics and Management
Author's institutionUniversity of Rijeka
Faculty of Civil Engineering
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Interdisciplinary Natural Sciences
Abstract (english)
Residing in the islets of Langerhans in the pancreas, beta cells contribute to glucose homeostasis by managing the body’s insulin supply. A circulating hypothesis has been that healthy beta cells heavily engage in cell-to- cell communication to perform their homeostatic function. We provide strong evidence in favor of this hypothesis in the form of (i) a dynamical network model that faithfully mimics fast calcium oscillations in response to above- threshold glucose stimulation and (ii) empirical data analysis that reveals a qualitative shift in the cross-correlation structure of measured signals below and above the threshold glucose concentration. Combined together, these results point to a glucose- induced transition in beta- cell activity thanks to increasing coordination through gapjunctional signaling and paracrine interactions. The model further suggests how the conservation of entire cell-cell conductance, observed in coupled but not uncoupled beta cells, emerges as a collective phenomenon. An overall implication is that improving the ability to monitor beta-cell signaling should offer means to better understand the pathogenesis of diabetes mellitus.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiophysical Journal
Numberingvol. 118, no. 10, pp. 2588-2595
p-ISSN0006-3495
DOIhttps://doi.org/10.1016/j.bpj.2020.04.005
URN:NBNurn:nbn:hr:157:390293
Publication2020-05
ProjectNumber: KK.01.1.1.01.009
Title (croatian): DATACROSS - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima
Title (english): Advanced methods and technologies in Data Science and Cooperative Systems
Acronym: DATACROSS
Leader: Sven Lončarić
Jurisdiction: eu
Funding stream: Cohesion Fund
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0006349520303088
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2025-04-02 12:53:54