According to statistics from the World Health Organization, traffic accidents are one of the leading causes of death among children and young people, and statistical indicators are even worse for the elderly population. Preventive measures require an approach that includes analyses of traffic infrastructure and regulations, users’ traffic behavior, and their interactions. In this study, a methodology based on traffic microsimulations was developed to select the optimal reconstruction solution for urban traffic infrastructure from the perspective of traffic safety. Comprehensive analyses of local traffic conditions at the selected location, infrastructural properties, and properties related to traffic users were carried out. The developed methodology was applied and tested at a selected unsignalized pedestrian crosswalk located in Osijek, Croatia, where traffic safety issues had been detected. Analyses of the possible solutions for traffic safety improvements were carried out, taking into account the specificities of the chosen location and the traffic participants’ behaviors, which were recorded and measured. The statistical analysis showed that children had shorter reaction times and crossed the street faster than the analyzed group of adult pedestrians, which was dominated by elderly people in this case. Using microsimulation traffic modeling (VISSIM), an analysis was conducted on the incoming vehicle speeds for both the existing and the reconstructed conflict zone solutions under different traffic conditions. The results exhibited a decrease in average speeds for the proposed solution, and traffic volume was detected to have a great impact on incoming speeds. The developed methodology proved to be effective in selecting a traffic solution that respects the needs of both motorized traffic and pedestrians.