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β Cells Operate Collectively to Help Maintain Glucose Homeostasis
Biophysical Journal, 118 (2020), 10; 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005
Podobnik, Boris; Korošak, Dean; Skelin Klemen, Maša; Stožer, Andraž; Dolenšek, Jurij; Slak Rupnik, Marjan; Ivanov, Plamen Ch.; Holme, Petter; Jusup, Marko

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Podobnik, B., Korošak, D., Skelin Klemen, M., Stožer, A., Dolenšek, J., Slak Rupnik, M. ... Jusup, M. (2020). β Cells Operate Collectively to Help Maintain Glucose Homeostasis. Biophysical Journal, 118. (10), 2588-2595. doi: 10.1016/j.bpj.2020.04.005

Podobnik, Boris, et al. "β Cells Operate Collectively to Help Maintain Glucose Homeostasis." Biophysical Journal, vol. 118, br. 10, 2020, str. 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005

Podobnik, Boris, Dean Korošak, Maša Skelin Klemen, Andraž Stožer, Jurij Dolenšek, Marjan Slak Rupnik, Plamen Ch. Ivanov, Petter Holme i Marko Jusup. "β Cells Operate Collectively to Help Maintain Glucose Homeostasis." Biophysical Journal 118, br. 10 (2020): 2588-2595. https://doi.org/10.1016/j.bpj.2020.04.005

Podobnik, B., et al. (2020) 'β Cells Operate Collectively to Help Maintain Glucose Homeostasis', Biophysical Journal, 118(10), str. 2588-2595. doi: 10.1016/j.bpj.2020.04.005

Podobnik B, Korošak D, Skelin Klemen M, Stožer A, Dolenšek J, Slak Rupnik M, i sur.. β Cells Operate Collectively to Help Maintain Glucose Homeostasis. Biophysical Journal [Internet]. 05.2020. [pristupljeno 05.04.2025.];118(10):2588-2595. doi: 10.1016/j.bpj.2020.04.005

B. Podobnik, et al., "β Cells Operate Collectively to Help Maintain Glucose Homeostasis", Biophysical Journal, vol. 118, br. 10, str. 2588-2595, Svibanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:157:390293. [Citirano: 05.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:157:390293
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Naslov (engleski)β Cells Operate Collectively to Help Maintain Glucose Homeostasis
AutorBoris Podobnik
AutorDean Korošak
AutorMaša Skelin Klemen
AutorAndraž Stožer
AutorJurij Dolenšek
AutorMarjan Slak Rupnik
AutorPlamen Ch. Ivanov
AutorPetter Holme
AutorMarko Jusup
Autorova ustanovaZagrebačka škola ekonomije i managementa
Autorova ustanovaSveučilište u Rijeci
Građevinski fakultet
Znanstveno / umjetničko
područje, polje i grana		PRIRODNE ZNANOSTI
Interdisciplinarne prirodne znanosti
Sažetak (engleski)
Residing in the islets of Langerhans in the pancreas, beta cells contribute to glucose homeostasis by managing the body’s insulin supply. A circulating hypothesis has been that healthy beta cells heavily engage in cell-to- cell communication to perform their homeostatic function. We provide strong evidence in favor of this hypothesis in the form of (i) a dynamical network model that faithfully mimics fast calcium oscillations in response to above- threshold glucose stimulation and (ii) empirical data analysis that reveals a qualitative shift in the cross-correlation structure of measured signals below and above the threshold glucose concentration. Combined together, these results point to a glucose- induced transition in beta- cell activity thanks to increasing coordination through gapjunctional signaling and paracrine interactions. The model further suggests how the conservation of entire cell-cell conductance, observed in coupled but not uncoupled beta cells, emerges as a collective phenomenon. An overall implication is that improving the ability to monitor beta-cell signaling should offer means to better understand the pathogenesis of diabetes mellitus.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiophysical Journal
Brojčani podacivol. 118, br. 10, str. 2588-2595
p-ISSN0006-3495
DOIhttps://doi.org/10.1016/j.bpj.2020.04.005
URN:NBNurn:nbn:hr:157:390293
Datum objave publikacije2020-05
ProjektŠifra: KK.01.1.1.01.009
Naziv (hrvatski): DATACROSS - Napredne metode i tehnologije u znanosti o podatcima i kooperativnim sustavima
Naziv (engleski): Advanced methods and technologies in Data Science and Cooperative Systems
Kratica: DATACROSS
Voditelj: Sven Lončarić
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: Cohesion Fund
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S0006349520303088
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2025-04-02 12:53:54